Detalhe da pesquisa
1.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 184(18): 4651-4668.e25, 2021 09 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34450028
2.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 179(2): 417-431.e19, 2019 Oct 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31585081
3.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 187(6): 1565-1566, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38490183
4.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 180(2): 406, 2020 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31978350
5.
An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia.
Blood
; 129(5): 609-618, 2017 02 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27908880
6.
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.
J Biol Chem
; 292(9): 3900-3908, 2017 03 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28077575
7.
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Proc Natl Acad Sci U S A
; 110(32): E2987-96, 2013 Aug 06.
Artigo
Inglês
| MEDLINE | ID: mdl-23882082
8.
Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines.
J Biol Chem
; 288(37): 26583-93, 2013 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-23880771
9.
CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun
; 14(1): 5053, 2023 08 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37598178
10.
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
J Exp Med
; 219(3)2022 03 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35226042
11.
Bivalent antibody pliers inhibit ß-tryptase by an allosteric mechanism dependent on the IgG hinge.
Nat Commun
; 11(1): 6435, 2020 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-33353951
12.
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody.
JCI Insight
; 5(7)2020 04 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32271166
13.
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32461332
14.
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32461331
15.
Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models.
Cancer Res
; 67(10): 4924-32, 2007 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17510422
16.
Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent.
Cancer Res
; 67(1): 254-61, 2007 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17210705
17.
Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library.
J Mol Biol
; 366(3): 815-29, 2007 Feb 23.
Artigo
Inglês
| MEDLINE | ID: mdl-17196977
18.
Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model.
Mol Cancer Ther
; 17(4): 776-785, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29339550
19.
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
Mol Cancer Ther
; 17(3): 638-649, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29282299
20.
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
J Clin Invest
; 128(5): 2144-2155, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29600961